The latest news from ANGLE
June 15, 2017
Barts Cancer Institute study finds rare type of cell in cancer patient blood linked to survival
Use of Parsortix identifies patients that are 10 times more likely to die of their disease early
ANGLE plc (AIM:AGL OTCQX:ANPCY), a world-leading liquid biopsy company, is delighted to announce that researchers from Queen Mary University of London’s Barts Cancer Institute (BCI), using ANGLE’s Parsortix system, have found a rare cell, known as a megakaryocyte, in the blood of prostate cancer patients and discovered that the number of these cells in the blood correlates closely with increased patient survival. This is the first time the presence of these cells in the blood has been shown to be connected to cancer prognosis.
The consequence of this finding is that, from a simple blood test, the Parsortix system has been shown to be capable of harvesting for analysis not only mesenchymal CTCs, which are linked to a poor outcome, but also megakaryocytes, which are linked to a favourable patient outcome. BCI researchers have shown in a 40 patient study that combining these two factors enables the identification of patients, who are 10 times more likely to die of their disease in the short term. This knowledge may enable targeted treatment, potentially improving patient outcomes.
Investigation of megakaryocytes in patient blood opens up a whole new area for cancer research and, at present, ANGLE’s patented Parsortix system is the only system that has been demonstrated to be capable of harvesting megakaryocytes.
ANGLE Founder and Chief Executive, Andrew Newland, commented:
“This is a key breakthrough for ANGLE’s Parsortix system showing further unique capabilities to harvest both rare megakaryocyte cells and mesenchymal CTCs in patient blood that play an essential role in the process of metastasis, which is responsible for over 90% of cancer deaths worldwide. The findings of this study are of great medical potential, demonstrating an ability to identify patients most at risk of aggressive prostate cancer and a higher rate of mortality and consequently most in need of intensive treatment.”
Dr Yong-Jie Lu, Reader in Medical Oncology at Barts Cancer Institute, commented:
“The discovery of the role of megakaryocytes in patient blood as a favourable prognostic biomarker has the potential to open up new avenues of research in the fight against cancer, not only in prostate cancer, but potentially other cancers too. Parsortix has shown the potential to detect more severe cancer cases where the patient is likely to die sooner, with a simple blood test, thereby providing information which may enable clinicians to provide different treatment for their patients, potentially extending lives of those battling with cancer.”
June 5, 2017
ANGLE plc (AIM:AGL OTCQX:ANPCY), the specialist medtech company, is pleased to announce that researchers have presented successful results from their work using ANGLE’s Parsortix system in colorectal cancer at the American Society of Clinical Oncology (ASCO) Annual Meeting 2017, in Chicago.
The study, undertaken by The University of Texas MD Anderson Cancer Center, represents the first ever analysis of meEGFR (arginine methylation of the epidermal growth factor receptor) status across a population of circulating tumour cells (CTCs) isolated from colorectal cancer patients being treated with EGFR inhibitors. meEGFR is already associated with a patient’s likely response to EGFR inhibitors, a key drug class in the treatment of colorectal cancer. The object of the study was therefore to assess whether the presence of meEGFR biomarker, when found in CTCs, is predictive of an adverse duration of progression-free survival (PFS) amongst this treatment group.
The results show that in a prospective study of 47 metastatic colorectal cancer patients, researchers were able to use the Parsortix system to harvest circulating tumour cells (CTCs) and were able to analyse these cells for the presence or absence of meEGFR.
May 3, 2017
ANGLE plc (AIM:AGL OTCQX:ANPCY), the specialist medtech company, is pleased to provide a business update following the close of its financial year ended 30 April 2017.
Ovarian Cancer Studies
The Company’s first clinical application for Parsortix is being progressed with two clinical studies in ovarian cancer: ANG-001 in Europe (200 patients) and ANG-003 in the United States (200 patients). The Company has made good progress in these studies and patient enrolment is now complete in both. A few patients remain to have their abnormal pelvic mass surgically removed and/or the removed tissue to be analysed to confirm the presence or absence of tumour cells. The studies will then be un-blinded and an independent statistical evaluation of the predictive power of the Parsortix clinical application will be undertaken. The headline data is on track for reporting this quarter (Q2 CY17).
The Company has successfully completed fundamental aspects of the FDA analytical study and the remaining tasks are in progress. The FDA clinical study, ANG-002 in metastatic breast cancer, has passed formal Scientific Review Committee approval and The University of Texas MD Anderson Cancer Center has been signed as the lead cancer centre for analysis of the primary endpoint and one of the secondary endpoints for the study. ANGLE has engaged with IRBs (institutional review boards) at six US cancer centres to provide patient samples and to process these with Parsortix for subsequent analysis. The studies remain on track for completion by the end of CY17.
April 3, 2017
ANGLE plc (AIM:AGL OTCQX:ANPCY), the specialist medtech company, is delighted to announce that the University of Athens and Attikon University Hospital, Greece are today presenting highly encouraging results from their work with ANGLE’s Parsortix system in head and neck squamous cell carcinomas at the American Association for Cancer Research conference (AACR) 2017, in Washington DC.
The results show that in a study of 40 cancer patients, the Parsortix system demonstrated higher sensitivity and greater purity in harvesting CTCs for analysis than leading alternative approaches. Information regarding the expression of key genes (including PD-L1 and CK-19) could be determined from simple blood samples taken from each patient. In parallel, identical samples from each patient were assessed using antibody-based (EpCAM-dependent) approaches. These approaches failed to detect PD-L1 or CK-19 in any of the 40 samples.
The University of Athens work suggest that, for the first time, it might be possible to assess gene expression of head and neck cancers using a Parsortix non-invasive liquid biopsy. Gene expression of biomarkers such as PD-L1 provides key information regarding likely patient response to immunotherapies and has the potential to be of significant clinical importance for the therapy selection and follow-up of patients.
Head and neck cancer is the sixth most common cancer worldwide with over 600,000 new patients diagnosed annually resulting in more than 350,000 deaths every year. More than 90% of head and neck cancers are squamous cell carcinomas (HNSCC) which account for 5-10% of all new cancer cases in Europe and North America.
March 30, 2017
ANGLE plc (AIM:AGL OTCQX:ANPCY), the specialist medtech company, is delighted to announce that researchers from the Barts Cancer Institute (BCI), Queen Mary University of London, have presented new results at the World CDx Europe 2017 conference in London of their work with ANGLE’s Parsortix system in prostate cancer. The new findings suggest a broader range of potential applications for Parsortix in prostate cancer from early to late disease prognosis.
Metastasis, the spread of cancer to another part of the body, is responsible for over 90% of cancer-related deaths. Consequently, a key issue in the treatment of prostate cancer is to determine whether the cancer has been contained or whether it is continuing to progress to metastasis. In the latter case, the earlier treatment can be deployed the better.
BCI have now completed a pilot study in over 80 patients to evaluate the capability of Parsortix to be used to identify whether prostate cancer patients have progressed to metastasis. The results presented today indicate that the use of Parsortix, in combination with existing assessments, is potentially more effective than existing parameters currently used to predict metastasis in identifying those patients who have progressed to metastasis.
February 13, 2017
ANGLE plc (AIM: AGL OTCQX: ANPCY), the specialist medtech company, is pleased to announce that it has been formally selected for CANCER-ID, the European consortium to validate blood-based biomarkers for cancer.
CANCER-ID is a European consortium funded by the Innovative Medicines Initiative (IMI), with a total budget exceeding €14 million, bringing together 38 partners from 13 countries, and aimed at the establishment of standard protocols for and clinical validation of blood-based biomarkers to enable liquid biopsies to become routine clinical practice.
University Medical Center Hamburg-Eppendorf, University of Twente, Bayer AG and Menarini Silicon Biosystems coordinate the consortium, bringing together experts from academic and clinical research to the life sciences industry to provide a unique setting to establish the clinical utility of liquid biopsies.
January 26, 2017
ANGLE plc (AIM:AGL OTCQX:ANPCY), the specialist medtech company, is delighted to announce the outcome from the planned interim evaluations of two separate 200 patient ovarian cancer studies, in Europe and the United States.
The early evaluation of data from both the studies suggest that an assay using the Parsortix system could accurately differentiate between women with a malignant pelvic mass and those with benign tumours, with an additional benefit of providing valuable gene expression information which could help further refine treatment decisions. Such data, if confirmed over the remaining samples, would represent an advantage over currently available clinical risk assessment tools.
ANGLE WELCOMES NEW RESEARCH FROM BARTS SUPPORTING POTENTIAL USE OF PARSORTIX TO DETECT AND MONITOR PROSTATE CANCER
November 4, 2016
ANGLE plc welcomes new research presented during the National Cancer Research Institute (NCRI) annual conference, 6-9 November 2016, which supports the potential use of the Company’s Parsortix cell separation technology. This research details the use of Parsortix as part of a simple blood test, to diagnose and monitor patients with prostate cancer.
September 30, 2016
ANGLE plc today announces that University Medical Centre Hamburg-Eppendorf (UKE) has published new research detailing the use of ANGLE’s ParsortixTM system in the prestigious peer-reviewed journal Clinical Chemistry. The paper is entitled “Accession of Tumor Heterogeneity by Multiplex Transcriptome Profiling of Single Circulating Tumor Cells” 1.
July 27, 2016
ANGLE plc is pleased to announce that it has initiated an ovarian cancer study in the United States, in addition to its recently opened European ovarian cancer study. The US study is being led by Dr Richard Moore at the University of Rochester Medical Center Wilmot Cancer Institute (New York State).